MEK Activity Regulates Negative Selection of Immature CD4+CD8+ Thymocytes
نویسندگان
چکیده
منابع مشابه
MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.
CD4+CD8+ thymocytes are either positively selected and subsequently mature to CD4 single positive (SP) or CD8 SP T cells, or they die by apoptosis due to neglect or negative selection. This clonal selection is essential for establishing a functional self-restricted T cell repertoire. Intracellular signals through the three known mitogen-activated protein (MAP) kinase pathways have been shown to...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2000
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.164.5.2326